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Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonaryconsolidation on computed tomography

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 585-593 doi: 10.1007/s11684-020-0817-2

摘要： Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China. Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included. Results showed that the severity-of-illness score for TEN (SCORTEN) had a good discrimination (area under the receiver operating characteristic curve (AUC), 0.78), and it was superior to auxiliary score (AS) and ABCD-10, which indicates age, bicarbonate level, cancer, dialysis, and 10% involved body surface area (AUC, 0.69 and 0.68, respectively). The calibration of SCORTEN (Hosmer–Lemeshow goodness-of-fit test, = 0.69) was also better than that of AS ( = 0.25) and ABCD-10 ( = 0.55). SCORTEN and ABCD-10 were similar (Brier score (BS), 0.04 and 0.04) in terms of accuracy of predictions. In addition, the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality. Refined models were formed using the variables and this imaging appearance. The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN (0.74 vs. 0.78, = 0.23; 0.74 vs. 0.78, = 0.30, respectively). Therefore, SCORTEN showed good discrimination performance, calibration, and accuracy, and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.

关键词： Stevens–Johnson syndrome     toxic epidermal necrolysis     auxiliary score     ABCD-10     pulmonary consolidation    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 425-432 doi: 10.1007/s11684-013-0295-x

摘要：

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.

关键词： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Survey on deep learning for pulmonary medical imaging

Jiechao Ma, Yang Song, Xi Tian, Yiting Hua, Rongguo Zhang, Jianlin Wu

《医学前沿（英文）》 2020年 第14卷 第4期   页码 450-469 doi: 10.1007/s11684-019-0726-4

摘要： As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful techniques in medical image areas. In this process, feature representations are learned directly and automatically from data, leading to remarkable breakthroughs in the medical field. Deep learning has been widely applied in medical imaging for improved image analysis. This paper reviews the major deep learning techniques in this time of rapid evolution and summarizes some of its key contributions and state-of-the-art outcomes. The topics include classification, detection, and segmentation tasks on medical image analysis with respect to pulmonary medical images, datasets, and benchmarks. A comprehensive overview of these methods implemented on various lung diseases consisting of pulmonary nodule diseases, pulmonary embolism, pneumonia, and interstitial lung disease is also provided. Lastly, the application of deep learning techniques to the medical image and an analysis of their future challenges and potential directions are discussed.

关键词： deep learning     neural networks     pulmonary medical image     survey    

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Split-order consolidation optimization for online supermarkets: Process analysis and optimization models

《工程管理前沿（英文）》   页码 499-516 doi: 10.1007/s42524-022-0221-5

摘要： The large-scale online supermarket is a newly emerging online retailing mode which brings great convenience to people. Online supermarkets are characterized by having large amounts of daily orders with potentially multiple items, diverse delivery times, and a high order-split rate. Multiple shipments for one order caused by order splitting result in high cost and disturbance and a large number of discarded consumable packages at online retailers and customers, causing severe damage to the environment. Accordingly, research on split-order consolidation fulfilment is critical for the advancement of the practice and theory in the context of highly complex online retailing. This paper first analyzes the characteristics and the challenges associated with the split-order consolidation problem that online supermarket is confronting and summarizes the new operational process of split-order consolidation fulfilment. Then, a time–space network optimization model is built, and its corresponding solution algorithm is presented to solve the questions of where and when to consolidate the split orders. Finally, the computation results of the numerical experiments are provided to verify the effectiveness of the algorithm, and a sensitivity analysis of the relevant parameters is performed. This work highlights the effect of order consolidation processes and fulfilment methods on the order fulfilment decision-making for online supermarkets. The purpose of this article is to help pave the way for more effective online supermarket management and order implementation.

关键词： online supermarkets     split-order consolidation     time–space network     genetic algorithm    

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A method for predicting consolidation settlements of floating column improved clayey subsoil

Jinchun CHAI, Supasit PONGSIVASATHIT,

《结构与土木工程前沿（英文）》 2010年 第4卷 第2期   页码 241-251 doi: 10.1007/s11709-010-0024-3

摘要： A method of predicting the consolidation settlement-time curve of floating soil-cement column on improved soft clayey subsoil has been proposed. The degree of the consolidation (()) of the system is calculated by the double soil-layer consolidation theory, and the methods for evaluating the equivalent hydraulic conductivity () and the coefficient of volume compressibility () of the part of the column improved layer have been proposed. The effectiveness of the method was verified by comparing predictions with the results of finite element analysis (FEA) using a unit cell model. The consolidation settlement (()) can be calculated by the method of treating a part of the column improved layer as an unimproved layer and using the corresponding average () value. By comparing the predicted results with the measurements of laboratory model tests and three case histories in Fukuoka, Japan, the effectiveness of the proposed methods has been verified. It is suggested that the method can be used for designing the soft clayey subsoil improvement using floating soil-cement columns.

关键词： cement depth mixing     ground improvement     consolidation     settlement    

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One-dimensional consolidation of over-consolidated soil under time-dependent loading

XIE Kanghe, WANG Kun, CHEN Guohong, HU Anfeng

《结构与土木工程前沿（英文）》 2008年 第2卷 第1期   页码 67-72 doi: 10.1007/s11709-008-0009-7

摘要： The problem of one-dimensional consolidation of over-consolidated saturated soil under time-dependent loading was studied based on semi-analytical method. The relevant computer code was developed by FORTRAN programming, and one-dimensional consolidation behavior of over-consolidated soil was investigated. It is shown that, unlike this described by traditional Terzaghi’s consolidation theory, the rate of excess pore water pressure dissipation is different from that of settlement developing. The magnitude of load and that of pre-consolidation pressure as well as the loading rate has all significant influence on consolidation. With the increasing of pre-consolidation pressure and loading rate, the rate of consolidation increases correspondingly. However, an increase in load will slow down the consolidation rate.

关键词： different     FORTRAN programming     Terzaghi ’     pre-consolidation     magnitude    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

《化学科学与工程前沿（英文）》 2010年 第4卷 第1期   页码 82-86 doi: 10.1007/s11705-009-0307-1

摘要： A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.

关键词： advanced engineering     improved     pressure     aqueous     technique    

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Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 354-366 doi: 10.1007/s11684-013-0257-3

摘要：

Due to the implementation of directly observed treatment strategy (DOTS), China has made a significant achievement in tackling the tuberculosis (TB) epidemic in the 1990s. However, only half of regions in China met or exceeded the 85% rate of treatment success target. The aim of the present study is to summarize the treatment outcomes of smear-positive pulmonary TB in the mainland of China in the past decade using meta-analysis based on systematic review of published observational studies. A total of 50 eligible articles (58 studies) were identified and included in this study. The summarized treatment success rates were 93.9% (95% CI, 92.8%–94.7%) for new cases and 85.4% (95% CI, 83.0%–87.6%) for previously treated cases, and the summarized cured rate were 92.2% (95% CI, 90.9%–93.3%) and 81.2% (95% CI, 79.1%–83.1%), respectively. A remarkable increase of rates for treatment success and cure was observed in the 1990s. After 2000, the summarized treatment outcomes were tending towards stability. In addition, geographic areas, type of the data and administrative level of the hospital were also found to influence the estimates of the treatment outcomes. Results of the present study clearly show, in general, that the pulmonary TB treatment achieved significant success in the past decade in the mainland of China. However, it needs to be further strengthened in the central and west areas.

关键词： tuberculosis     treatment     outcome     China     meta-analysis    

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Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 395-395 doi: 10.1007/s11684-013-0289-8

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Clinical characteristics in lymphangioleiomyomatosis-related pulmonary hypertension: an observation on

Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu

《医学前沿（英文）》 2019年 第13卷 第2期   页码 259-266 doi: 10.1007/s11684-018-0634-z

摘要： Lymphangioleiomyomatosis (LAM) is a rare diffuse cystic lung disease. Knowledge on LAM-related pulmonary hypertension (PH) is limited. This study aimed to analyze the clinical characteristics of LAM with elevated pulmonary artery pressure (PAP) and evaluate the potential efficacy of sirolimus. The study involved 50 LAM patients who underwent echocardiography. According to the tricuspid regurgitation velocity (TRV), these patients were divided into the TRV≤2.8 m/s group and TRV>2.8 m/s group. Both groups comprised 25 females with an average age of 38.6±8.1 and 41.5±8.9 years. In the TRV>2.8 m/s group, the estimated systolic PAP (SPAP) was significantly elevated (52.08±12.45 mmHg vs. 30.24±5.25mmHg, <0.01). Linear analysis showed that SPAP was correlated with forced expiratory volume in 1 s (FEV ), diffusing capacity of the lungs for carbon monoxide, alveolar arterial oxygen gradient (P O ), and 6 min walking distance ( = −0.392, −0.351, 0.450, and −0.591, respectively; <0.05), in which P O was a risk factor for SPAP elevation ( = 0.064, OR= 1.066, <0.05). Moreover, in 10 patients who received sirolimus therapy, SPAP decreased from 57.0±12.6 mmHg to 35.2±11.1 mmHg. The study showed that LAM patients with PH exhibit poor pulmonary function and hypoxemia and may benefit from sirolimus treatment.

关键词： lymphangioleiomyomatosis     pulmonary hypertension     pulmonary function     hypoxemia     sirolimus    

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Dimensionality reduction and prediction of soil consolidation coefficient using random forest coupling

Hai-Bang LY; Huong-Lan Thi VU; Lanh Si HO; Binh Thai PHAM

《结构与土木工程前沿（英文）》 2022年 第16卷 第2期   页码 224-238 doi: 10.1007/s11709-022-0812-6

摘要： The consolidation coefficient of soil (Cv) is a crucial parameter used for the design of structures leaned on soft soi. In general, the Cv is determined experimentally in the laboratory. However, the experimental tests are time-consuming as well as expensive. Therefore, researchers tried several ways to determine Cv via other simple soil parameters. In this study, we developed a hybrid model of Random Forest coupling with a Relief algorithm (RF-RL) to predict the Cv of soil. To conduct this study, a database of soil parameters collected from a case study region in Vietnam was used for modeling. The performance of the proposed models was assessed via statistical indicators, namely Coefficient of determination (R2), Root Mean Squared Error (RMSE), and Mean Absolute Error (MAE). The proposal models were constructed with four sets of soil variables, including 6, 7, 8, and 13 inputs. The results revealed that all models performed well with a high performance (R2 > 0.980). Although the RF-RL model with 13 variables has the highest prediction accuracy ( R2 = 0.9869), the difference compared with other models was negligible (i.e., R2 = 0.9824, 0.9850, 0.9825 for the cases with 6, 7, 8 inputs, respectively). Thus, it can be concluded that the hybrid model of RF-RL can be employed to predict Cv based on the basic soil parameters.

关键词： soil consolidation coefficient     machine learning     random forest     Relief    

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Clinical characteristics of pulmonary hypertension in bronchiectasis

null

《医学前沿（英文）》 2016年 第10卷 第3期   页码 336-344 doi: 10.1007/s11684-016-0461-z

摘要：

Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent PH were included in the study. Patient characteristics at baseline and during follow-up, as well as survival, were analyzed. This observational study was conducted in 36 patients with a mean age of 51.5 years (range, 17?74 years). The 6 min walking distance was 300.8±93.3 m. The mean pulmonary arterial pressure (PAP) was 41.5±11.7 mmHg, cardiac output was 5.2±1.4 L/min, and pulmonary vascular resistance was 561.5±281.5 dyn·s·cm−5. The mean PAP was>35 mmHg in 75% of the cases. Mean PAP was inversely correlated with arterial oxygen saturation values (r = −0.45, P = 0.02). In 24 patients who received oral PAH therapy, systolic PAP was reduced from 82.4±27.0 mmHg to 65.5±20.9 mmHg (P = 0.025) on echocardiography after a median of 6 months of follow-up. The overall probability of survival was 97.1% at 1 year, 83.4% at 3 years, and 64.5% at 5 years. Given the results, we conclude that PH with severe hemodynamic impairment can occur in patients with bilateral bronchiectasis, and PAH therapy might improve hemodynamics in such patients. Prospective clinical trials focusing on this patient population are warranted.

关键词： bronchiectasis     hemodynamics     pulmonary hypertension    

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高饱和土固结及饱和度对土体固结的影响

金志高

《中国工程科学》 2004年 第6卷 第9期   页码 73-76

摘要：

以Terzaghi土体固结理论和Biot固结理论为基础，按饱和度不同的分类，研究了高饱和土固结机理及过程，深入分析了高饱和土饱和度变化对孔隙流体压缩性的影响，以及由此影响到高饱和土的固结全过程。

关键词： 固结     饱和度     体变模量     压缩    

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Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

《医学前沿（英文）》 2008年 第2卷 第3期   页码 314-316 doi: 10.1007/s11684-008-0060-8

摘要： The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats. A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin. On days 14, 28 and 45, the contents of laminin, collagen I and collagen III in lung tissue homogenate in the model group, the sham operated group, the Feixian group and the prednisone group were measured. The contents of laminin and collagen I and III were decreased significantly by the Feixian Recipe. Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

关键词： bleomycin     intratracheal injection     prednisone     collagen     bleomycin-induced pulmonary    

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mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

《医学前沿（英文）》 2021年 第15卷 第2期   页码 313-329 doi: 10.1007/s11684-020-0737-1

摘要： The medical fungus has been used as a Chinese folk health supplement because of its immunomodulatory properties. Our previous studies established the antifibrotic action of mycelium (HSM) in the lung. The epithelial–mesenchymal transition (EMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis. The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis. HSM significantly inhibits bleomycin (BLM)-induced pulmonary fibrosis by blocking the EMT. In addition, the expression levels of midkine are increased in the lungs of the BLM-induced group. Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT. HSM markedly abrogates the transforming growth factor β-induced EMT-like phenotype and behavior . The activation of midkine related signaling pathway is ameliorated following HSM treatment, whereas this extract also caused an effective attenuation of the induction of EMT (caused by midkine overexpression) . Results further confirm that oral medication of HSM disrupted the midkine pathway . Overall, findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM.

关键词： epithelial−mesenchymal transition     H. sinensis mycelium     midkine     pulmonary fibrosis    

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标题 作者 时间 类型 操作

Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonaryconsolidation on computed tomography

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

期刊论文

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

null

期刊论文

Survey on deep learning for pulmonary medical imaging

Jiechao Ma, Yang Song, Xi Tian, Yiting Hua, Rongguo Zhang, Jianlin Wu

期刊论文

Split-order consolidation optimization for online supermarkets: Process analysis and optimization models

期刊论文

A method for predicting consolidation settlements of floating column improved clayey subsoil

Jinchun CHAI, Supasit PONGSIVASATHIT,

期刊论文

One-dimensional consolidation of over-consolidated soil under time-dependent loading

XIE Kanghe, WANG Kun, CHEN Guohong, HU Anfeng

期刊论文

Protein microspheres for pulmonary drug delivery

Yongda SUN,

期刊论文

Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

null

期刊论文

Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

null

期刊论文

Clinical characteristics in lymphangioleiomyomatosis-related pulmonary hypertension: an observation on

Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu

期刊论文

Dimensionality reduction and prediction of soil consolidation coefficient using random forest coupling

Hai-Bang LY; Huong-Lan Thi VU; Lanh Si HO; Binh Thai PHAM

期刊论文

Clinical characteristics of pulmonary hypertension in bronchiectasis

null

期刊论文

高饱和土固结及饱和度对土体固结的影响

金志高

期刊论文

Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

期刊论文

mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

期刊论文